Advancing Benchmarks for Genome Sequencing

Advancing the Materials Genome

The term, Materials Genome (a registered trademark of MaterialsGenome, Inc., Pennsylvania, USA) was coined by the present author in 2002 and recently used with consent in the “Materials Genome Initiative” by the White House Office of Science and Technology Policy. In this paper, the author’s perspectives on Materials Genome, i.e. the building blocks of materials, will be illustrated with severa...

For Genome Sequencing Submission:

We are resubmitting as an attachment a white paper requesting an 8-fold coverage draft genome sequence for the opisthobranch mollusc, Aplysia californica. As described in the proposal, Aplysia is a major model organism for studies in cellular, molecular and behavioral neuroscience, integrative physiology and system biology. It is also ideally placed taxonomically to serve as an important organi...

Advancing Chimeric Antigen Receptor-Engineered T-Cell Immunotherapy Using Genome Editing Technologies: Challenges and Future Prospects

Chimeric antigen receptor engineered-T (CAR-T) cells also named as living drugs, have been recently known as a breakthrough technology and were applied as an adoptive immunotherapy against different types of cancer. They also attracted widespread interest because of the success of B-cell malignancy therapy achieved by anti-CD19 CAR-T cells. Current genetic toolbox enabled the synthesis of CARs ...

Genome Sequencing

The concept of genome sequencing is quite simple. Break your genome up into many different small fragments, clone those fragments into a cloning vector, isolate many clones, and sequence each clone. All of the techniques used for sequencing are well established. These are the same techniques that scientists used for the past twenty years to characterize many different individual genes. Using th...

Whole Genome Sequencing: An Efficient Approach in Food Safety Management System